2025 International Conference on Digital Humanities and Socio-Cultural Innovation (DHSCI 2025) will be held on December 26-28, 2025, in Sanya, China. DHSCI 2025 aims to establish an interdisciplinary global platform for advancing the integration of digital technologies with humanities research and socio-cultural innovation. This conference will gather leading scholars, engineers, and industry experts to explore cutting-edge applications of artificial intelligence, big data analytics, digital twins, and related technologies in fields such as cultural heritage preservation, social group behavior analysis, digital storytelling, and artistic creation. Through keynote speeches, academic workshops, case exhibitions, and roundtable discussions, DHSCI 2025 seeks to foster methodological innovation in technology-enhanced interdisciplinary research and promote the sustainable development of socio-cultural values. Researchers worldwide are invited to join us in Sanya to collectively reshape humanities scholarship in the digital age through academic-industry collaboration.